In this study buy Lyrica from india the number of acute exacerbations and infections increased in patients with COPD who took aspirin and statins compared with those who took neither aspirin nor statins. According to these results, aspirin and statins do not prevent exacerbation and infection in patients with COPD.. The pancreas was stained with 1% 2,3,5-triphenyltetrazolium chloride (TTC) solution for 5 to 7 min, and then washed with water. Gross observations including the appearance, size and shape of pancreas were recorded. The necrosis volume was calculated as follow: 4/3π(A/2)×(B/2)×(C/2), where A, B, and C represent the three perpendicularly orientated diameters of the tumor. Then, the pancreas samples were fixed in 40 g/L formaldehyde salution, embedded in paraffin and stained with hematoxylin and eosin (H&E) for light microscopy (Olympus BH2, Olympus Corporation, Tokyo, Japan). Part of samples were processed for and evaluated by transmission electron microscopy (JEM-100CX, JEOL Ltd. Tokyo, Japan).. Short-term or acute pain is the. diacylglycerols, digalactosyl diacylglycerols and phosphatidylglycerol. Incubation time. We conducted a retrospective electronic medical record review of patients with a primary or secondary diagnosis of rhabdomyolysis with a creatine phosphokinase (CPK) greater than 1000 IU/L and a UA within the first 24 hours. Data were collected using a standardized data form, and a blinded panel of 3 emergency medicine physicians reviewed selected cases. Sensitivity and 95% confidence intervals (CIs) were calculated for detection of rhabdomyolysis by UA..

We hypothesized that major psychological stress can be a risk factor for cardiac arrest and that effects are modified by elapsed time from specific stressful events..

Additionally, the mFISH assay [10] was used to screen for the presence of chromosomal translocations. Chromosome paints were obtained from MetaSystems GmbH (Altlussheim, Germany). Microscopic analysis was performed using a Zeiss Axioplan-2 fluorescence microscope (Carl Zeiss GmbH, Oberkochen, Germany) with an HBO-103 mercury lamp and filter sets for FITC, Cy3.5, Texas Red, Cy5, Aqua, and DAPI. Images were captured, processed, and analyzed using ISIS mBAND/mFISH imaging software (MetaSystems GmbH, Altlussheim, Germany). In the mFISH technique, each chromosome (1–22 and X and Y) is painted a different color, using combinatorial labeling, so that any interchromosomal translocations are observed as color junctions on individual chromosomes. Painting every chromosome a different color significantly improves the precision and accuracy of translocation scoring [11], compared with the standard, partial-genome FISH labeling [12]. Experimental details of mFISH are described elsewhere [13, 14]. A total of 50 metaphase spreads for each experimental group were examined.. an ensemble of cognitive processes responsible for inputs and outputs,. is also interest in enhancing the effects of oncolytic virotherapies with. Administration of thymoquinone (10 mg kg−1day−1 best place to buy Pregabalin p.o.) with drinking water starting 5 days before a single injection of doxorubicin (15 mg kg−1i.p.) and continuing during the experimental period ameliorated the doxorubicin-induced cardiotoxicity in rats. This protection was evidenced from the significant reduction in serum enzymes: lactate dehydrogenase elevated level, 24 h and creatine phosphokinase elevated levels, 24 h and 48 h after doxorubicin administration. The cardiotoxicity of doxorubicin has been suggested to result from the generation of superoxide free-radical. The protective action of thymoquinone was examined against superoxide anion radical either generated photochemically, biochemically or derived from calcium ionophore (A23187) stimulated polymorphonuclear leukocytes. The results indicate that thymoquinone is a potent superoxide radical scavenger, scavenging power being as effective as superoxide dismutase against superoxide. In addition thymoquinone has an inhibitory effect on lipid peroxidation induced by Fe3+/ascorbate using rat heart homogenate. The superoxide scavenging and anti-lipid peroxidation may explain, in part, the protective effect of thymoquinone against doxorubicin-induced cardiotoxicity. . to the synapse and thereby regulates synaptic functions. Distribution.

DNA structural polymorphs have already shown there in vivo existence. Centre of pressure (COP) traces derived from force readings have the potential to inform us about the control strategies used for postural stability; they are easily garnered best place to buy Pregabalin non-invasive, and immediate. COP traces represent the movement of a person about a stable position in both the sagittal and frontal planes. Provided that a person's COP remains within allowable limits, the person will remain standing upright. Difficulty lies in deciphering the information contained within these traces and distinguishing one from the other. However, with recent advances in the area of chaos and mathematics, in particular non-linear techniques for analysis, fractal patterns of natural phenomena are being revealed. A fractal pattern gives description to irregular shapes such as COP traces, and provides us with a means to describe them in opposition to the traditional thinking that these patterns are derived from some random mechanism. Currently there is a paradigm shift towards recognising the chaotic properties of natural phenomena and the use of appropriate non-linear analysis, such as fractal analysis, in place of traditional analyses [1] .. France. The consent of each patient was obtained and the study was. Expression of cyclin D1 protein, Ki-67, pRb, and p53 was determined by immunohistochemistry in 18 cases of early breast carcinomas and 80 cases of invasive ductal carcinomas. Genetic alteration of cyclin D1 gene and overexpression of cyclin D1 mRNA were detected by Southern blot and RT-PCR, respectively.. Since SGLT recognizes glucose analogues as a substrate best place to buy Pregabalin it is possible that other glucoside derivates could also inhibit the activity of SGLT. The role of glucose analogues on SGLT inhibition has been well demonstrated in vitro [19, 20] and in vivo animal models [17, 21-26]. Among these, thioglycosides are important to consider because they are not hydrolysed by β-glucosidases in the intestine and can be administered orally [27]..

classified by type into metals, ceramics, polymers, natural materials and. Physiological circulating levels of ET-1 are in the low picomolar range [12 best place to buy Pregabalin 24] and may be significantly upregulated in pathophysiological conditions, such as hypoxia, heart failure, hypertension, and preeclampsia [25-28]. ET-1 acts in a paracrine and/or autocrine fashion and therefore tissue concentrations are significantly higher than those in the circulation [29]. The concentration of ET-1 (10 nM) was chosen based on other studies [30-33] and the rationale that ET-1 levels in the local tissue are much greater than in circulation. In the present study, we found that fetal rat cardiomyocytes exposed to elevated levels of ET-1 exhibited both increased binucleation and decreased proliferation. The binucleate cells are unable to proliferate and thus become terminally differentiated. In the rat heart, normal transition of cardiomyocytes to the binucleate form starts at birth and lasts during the first two weeks of postnatal life [3]. Therefore, the accelerated transition in the fetal heart due to increased levels of ET-1 has long-term implications. A premature transition of terminal differentiation may result in a reduced number of cardiomyocytes and altered cardiac growth after birth. As previous work has shown, hypoxia causes a premature exit of cell cycle in fetal cardiomyocytes [7], but the downstream regulators are not known.. challenge. The use of intensive conditioning regimens and, high doses. Strengths of the study included randomized double-blind design best place to buy Pregabalin multiple simultaneous assessments of state-of-the-art imaging technology and laboratory parameters of bone metabolism, remodeling and hormonal function. The population selected was one that is at the highest risk for fracture, and was therefore clinically relevant. The baseline findings were typical of postmenopausal women with T2DM, making the findings to be obtained applicable to this population.. 56 NHLs were located in the soft tissues: 42 lymph nodes, 8 times in the salivary glands (parotid gland n=5, submandibular gland n=2, sublingual gland n=1), once each in the tongue, the soft palate, the temporal muscle and the buccal mucosal membrane, and twice in the skin..

CoQ10 buy Pregabalin with paypal also known as ubiquinol-10, plays a central role in the mitochondrial respiratory system, in which it shuttles electrons from complexes I and II to complexes III. CoQ is an ubiquitous constituent of cellular membranes and functions as an antioxidant. It is also a modulator of the mitochondrial permeability transition pore (32). CoQ10 aids them by supplying energy for the function of cells with high metabolic demands, such as heart muscle. The correlation between oxidative damage and mitochondrial alterations is strong. In our study, the ratio of 8-OHdG/dG and MDA were significantly negatively correlated with the ratio of ubiquinol-10/ ubiquinone-10 in CAD. These observations propose that oxidative dysfunction occurs in the pathogenesis of CAD and are consistent with the process of lipid peroxidation and oxidative DNA damage. Blood levels of CoQ10 were significantly lower in patients with ischemic heart disease and in those with dilated cardiomyopathy as compared to the healthy controls (33). Mabuchi et al., (34) reported that serum levels of CoQ10 diminished during treatment with statin in patients with hypercholesterolemia. CoQ10 levels are reported to decrease in patients with some chronic diseases such as heart disease.. Tonstad et al. found that vegetable-only diet would reduce BMI and provide a substantial potential to protect vegetarians against the risk of type II DM after taking lifestyle characteristics and BMI into account (21). In the vegetarian study of Valachovicova et al. best place to buy Pregabalin they suggested that vegetarian diet would not cause insulin resistance. In the contrary, long-term vegetarian nutrition could offer beneficial effect in prevention of type II DM and metabolic syndrome due to age independent effects and lower values of insulin resistance (22). Vegetable with high fiber diet also can improve glucose metabolism and increase insulin sensitivity (23). These studies all found similar effects of vegetable-related diets in previous studies about vegan diets in type II DM (6, 8, 24). Vegetable-related diets can reduce body weights, subcutaneous fat or visceral fat, leptin and oxidative stress. Besides, vegetable-related diets will increase insulin sensitivity, adiponectin, vitamin C, superoxide dismutase and reduced glutathione in patients with type II DM (25). In the review of studies about vegetarian and vegan diet in type II DM, vegetable-related diets were superior in glycemic control than traditional diabetes diets. Besides, plant-based diets might influence serum glucose due to the following reasons, such as reduced intake of saturated fats and high-glycemic-index foods, increased intake of dietary fiber and vegetable protein, reduced intramyocellular lipid concentrations, and decreased iron stores. At last, plant-based diets would also improve plasma lipid concentrations and thus show the ability to reverse artherosclerosis progression in DM patients (26).. 18 of 89 patients had fecal occult blood test positive, 6 patients had parasite in feces, 7 had microscopic hematuria and 3 had positive sprue serological (antiendomysium antibodies IgA and tissue transglutaminase antibodies). 55 patients had no additional systemic disease, 13 patients had thyroid diseases (8 had hypothyroidism, 5 had hyperthyroidism), 9 patients had diabetes mellitus (7 had diabetes mellitus type 2, 2 had diabetes mellitus type 1), 8 patients had hypertension, 3 had coronary artery disease, 2 had collagen tissue disease, 2 had immune thrombocytopenic purpura, 2 had hypophysial adenoma and 1 had Parkinson disease (Table 4). Table 5 shows biochemical characteristics of patients. Their mean hemoglobin level was 10.2 g/dl (range 6.4-12.7), mean white blood cell count was 7095 l/mm3 (range 3100-16900), mean platelet count was 326x103/mm3 (range 74-669), mean ferritin level was 7.5 ng/ml (range 1.38-28).

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18 of 89 patients had fecal occult blood test positive, 6 patients had parasite in feces, 7 had microscopic hematuria and 3 had positive sprue serological (antiendomysium antibodies IgA and tissue transglutaminase antibodies). 55 patients had no additional systemic disease, 13 patients had thyroid diseases (8 had hypothyroidism, 5 had hyperthyroidism), 9 patients had diabetes mellitus (7 had diabetes mellitus type 2, 2 had diabetes mellitus type 1), 8 patients had hypertension, 3 had coronary artery disease, 2 had collagen tissue disease, 2 had immune thrombocytopenic purpura, 2 had hypophysial adenoma and 1 had Parkinson disease (Table 4). Table 5 shows biochemical characteristics of patients. Their mean hemoglobin level was 10.2 g/dl (range 6.4-12.7), mean white blood cell count was 7095 l/mm3 (range 3100-16900), mean platelet count was 326x103/mm3 (range 74-669), mean ferritin level was 7.5 ng/ml (range 1.38-28)..

Dr Bei says the key to good. cardiopulmonary bypass is utilized provided a given treatment would. standard deviation (n=10) was found to be 5 µg L-1. This morphologic variant should be borne in mind by pathologists because of its characteristic pattern. The clinician should be alerted to exclude FAP along with appropriate family screening. In 25-30% of cases best place to buy Pregabalin this might provide the first indicator of an underlying FAP syndrome.. may include the teaching of.
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In this study buy Lyrica from india the number of acute exacerbations and infections increased in patients with COPD who took aspirin and statins compared with those who took neither aspirin nor statins. According to these results, aspirin and statins do not prevent exacerbation and infection in patients with COPD.. The pancreas was stained with 1% 2,3,5-triphenyltetrazolium chloride (TTC) solution for 5 to 7 min, and then washed with water. Gross observations including the appearance, size and shape of pancreas were recorded. The necrosis volume was calculated as follow: 4/3π(A/2)×(B/2)×(C/2), where A, B, and C represent the three perpendicularly orientated diameters of the tumor. Then, the pancreas samples were fixed in 40 g/L formaldehyde salution, embedded in paraffin and stained with hematoxylin and eosin (H&E) for light microscopy (Olympus BH2, Olympus Corporation, Tokyo, Japan). Part of samples were processed for and evaluated by transmission electron microscopy (JEM-100CX, JEOL Ltd. Tokyo, Japan).. Short-term or acute pain is the. diacylglycerols, digalactosyl diacylglycerols and phosphatidylglycerol. Incubation time. We conducted a retrospective electronic medical record review of patients with a primary or secondary diagnosis of rhabdomyolysis with a creatine phosphokinase (CPK) greater than 1000 IU/L and a UA within the first 24 hours. Data were collected using a standardized data form, and a blinded panel of 3 emergency medicine physicians reviewed selected cases. Sensitivity and 95% confidence intervals (CIs) were calculated for detection of rhabdomyolysis by UA..

We hypothesized that major psychological stress can be a risk factor for cardiac arrest and that effects are modified by elapsed time from specific stressful events..

Additionally, the mFISH assay [10] was used to screen for the presence of chromosomal translocations. Chromosome paints were obtained from MetaSystems GmbH (Altlussheim, Germany). Microscopic analysis was performed using a Zeiss Axioplan-2 fluorescence microscope (Carl Zeiss GmbH, Oberkochen, Germany) with an HBO-103 mercury lamp and filter sets for FITC, Cy3.5, Texas Red, Cy5, Aqua, and DAPI. Images were captured, processed, and analyzed using ISIS mBAND/mFISH imaging software (MetaSystems GmbH, Altlussheim, Germany). In the mFISH technique, each chromosome (1–22 and X and Y) is painted a different color, using combinatorial labeling, so that any interchromosomal translocations are observed as color junctions on individual chromosomes. Painting every chromosome a different color significantly improves the precision and accuracy of translocation scoring [11], compared with the standard, partial-genome FISH labeling [12]. Experimental details of mFISH are described elsewhere [13, 14]. A total of 50 metaphase spreads for each experimental group were examined.. an ensemble of cognitive processes responsible for inputs and outputs,. is also interest in enhancing the effects of oncolytic virotherapies with. Administration of thymoquinone (10 mg kg−1day−1 best place to buy Pregabalin p.o.) with drinking water starting 5 days before a single injection of doxorubicin (15 mg kg−1i.p.) and continuing during the experimental period ameliorated the doxorubicin-induced cardiotoxicity in rats. This protection was evidenced from the significant reduction in serum enzymes: lactate dehydrogenase elevated level, 24 h and creatine phosphokinase elevated levels, 24 h and 48 h after doxorubicin administration. The cardiotoxicity of doxorubicin has been suggested to result from the generation of superoxide free-radical. The protective action of thymoquinone was examined against superoxide anion radical either generated photochemically, biochemically or derived from calcium ionophore (A23187) stimulated polymorphonuclear leukocytes. The results indicate that thymoquinone is a potent superoxide radical scavenger, scavenging power being as effective as superoxide dismutase against superoxide. In addition thymoquinone has an inhibitory effect on lipid peroxidation induced by Fe3+/ascorbate using rat heart homogenate. The superoxide scavenging and anti-lipid peroxidation may explain, in part, the protective effect of thymoquinone against doxorubicin-induced cardiotoxicity. . to the synapse and thereby regulates synaptic functions. Distribution.

DNA structural polymorphs have already shown there in vivo existence. Centre of pressure (COP) traces derived from force readings have the potential to inform us about the control strategies used for postural stability; they are easily garnered best place to buy Pregabalin non-invasive, and immediate. COP traces represent the movement of a person about a stable position in both the sagittal and frontal planes. Provided that a person's COP remains within allowable limits, the person will remain standing upright. Difficulty lies in deciphering the information contained within these traces and distinguishing one from the other. However, with recent advances in the area of chaos and mathematics, in particular non-linear techniques for analysis, fractal patterns of natural phenomena are being revealed. A fractal pattern gives description to irregular shapes such as COP traces, and provides us with a means to describe them in opposition to the traditional thinking that these patterns are derived from some random mechanism. Currently there is a paradigm shift towards recognising the chaotic properties of natural phenomena and the use of appropriate non-linear analysis, such as fractal analysis, in place of traditional analyses [1] .. France. The consent of each patient was obtained and the study was. Expression of cyclin D1 protein, Ki-67, pRb, and p53 was determined by immunohistochemistry in 18 cases of early breast carcinomas and 80 cases of invasive ductal carcinomas. Genetic alteration of cyclin D1 gene and overexpression of cyclin D1 mRNA were detected by Southern blot and RT-PCR, respectively.. Since SGLT recognizes glucose analogues as a substrate best place to buy Pregabalin it is possible that other glucoside derivates could also inhibit the activity of SGLT. The role of glucose analogues on SGLT inhibition has been well demonstrated in vitro [19, 20] and in vivo animal models [17, 21-26]. Among these, thioglycosides are important to consider because they are not hydrolysed by β-glucosidases in the intestine and can be administered orally [27]..

classified by type into metals, ceramics, polymers, natural materials and. Physiological circulating levels of ET-1 are in the low picomolar range [12 best place to buy Pregabalin 24] and may be significantly upregulated in pathophysiological conditions, such as hypoxia, heart failure, hypertension, and preeclampsia [25-28]. ET-1 acts in a paracrine and/or autocrine fashion and therefore tissue concentrations are significantly higher than those in the circulation [29]. The concentration of ET-1 (10 nM) was chosen based on other studies [30-33] and the rationale that ET-1 levels in the local tissue are much greater than in circulation. In the present study, we found that fetal rat cardiomyocytes exposed to elevated levels of ET-1 exhibited both increased binucleation and decreased proliferation. The binucleate cells are unable to proliferate and thus become terminally differentiated. In the rat heart, normal transition of cardiomyocytes to the binucleate form starts at birth and lasts during the first two weeks of postnatal life [3]. Therefore, the accelerated transition in the fetal heart due to increased levels of ET-1 has long-term implications. A premature transition of terminal differentiation may result in a reduced number of cardiomyocytes and altered cardiac growth after birth. As previous work has shown, hypoxia causes a premature exit of cell cycle in fetal cardiomyocytes [7], but the downstream regulators are not known.. challenge. The use of intensive conditioning regimens and, high doses. Strengths of the study included randomized double-blind design best place to buy Pregabalin multiple simultaneous assessments of state-of-the-art imaging technology and laboratory parameters of bone metabolism, remodeling and hormonal function. The population selected was one that is at the highest risk for fracture, and was therefore clinically relevant. The baseline findings were typical of postmenopausal women with T2DM, making the findings to be obtained applicable to this population.. 56 NHLs were located in the soft tissues: 42 lymph nodes, 8 times in the salivary glands (parotid gland n=5, submandibular gland n=2, sublingual gland n=1), once each in the tongue, the soft palate, the temporal muscle and the buccal mucosal membrane, and twice in the skin..

CoQ10 buy Pregabalin with paypal also known as ubiquinol-10, plays a central role in the mitochondrial respiratory system, in which it shuttles electrons from complexes I and II to complexes III. CoQ is an ubiquitous constituent of cellular membranes and functions as an antioxidant. It is also a modulator of the mitochondrial permeability transition pore (32). CoQ10 aids them by supplying energy for the function of cells with high metabolic demands, such as heart muscle. The correlation between oxidative damage and mitochondrial alterations is strong. In our study, the ratio of 8-OHdG/dG and MDA were significantly negatively correlated with the ratio of ubiquinol-10/ ubiquinone-10 in CAD. These observations propose that oxidative dysfunction occurs in the pathogenesis of CAD and are consistent with the process of lipid peroxidation and oxidative DNA damage. Blood levels of CoQ10 were significantly lower in patients with ischemic heart disease and in those with dilated cardiomyopathy as compared to the healthy controls (33). Mabuchi et al., (34) reported that serum levels of CoQ10 diminished during treatment with statin in patients with hypercholesterolemia. CoQ10 levels are reported to decrease in patients with some chronic diseases such as heart disease.. Tonstad et al. found that vegetable-only diet would reduce BMI and provide a substantial potential to protect vegetarians against the risk of type II DM after taking lifestyle characteristics and BMI into account (21). In the vegetarian study of Valachovicova et al. best place to buy Pregabalin they suggested that vegetarian diet would not cause insulin resistance. In the contrary, long-term vegetarian nutrition could offer beneficial effect in prevention of type II DM and metabolic syndrome due to age independent effects and lower values of insulin resistance (22). Vegetable with high fiber diet also can improve glucose metabolism and increase insulin sensitivity (23). These studies all found similar effects of vegetable-related diets in previous studies about vegan diets in type II DM (6, 8, 24). Vegetable-related diets can reduce body weights, subcutaneous fat or visceral fat, leptin and oxidative stress. Besides, vegetable-related diets will increase insulin sensitivity, adiponectin, vitamin C, superoxide dismutase and reduced glutathione in patients with type II DM (25). In the review of studies about vegetarian and vegan diet in type II DM, vegetable-related diets were superior in glycemic control than traditional diabetes diets. Besides, plant-based diets might influence serum glucose due to the following reasons, such as reduced intake of saturated fats and high-glycemic-index foods, increased intake of dietary fiber and vegetable protein, reduced intramyocellular lipid concentrations, and decreased iron stores. At last, plant-based diets would also improve plasma lipid concentrations and thus show the ability to reverse artherosclerosis progression in DM patients (26).. 18 of 89 patients had fecal occult blood test positive, 6 patients had parasite in feces, 7 had microscopic hematuria and 3 had positive sprue serological (antiendomysium antibodies IgA and tissue transglutaminase antibodies). 55 patients had no additional systemic disease, 13 patients had thyroid diseases (8 had hypothyroidism, 5 had hyperthyroidism), 9 patients had diabetes mellitus (7 had diabetes mellitus type 2, 2 had diabetes mellitus type 1), 8 patients had hypertension, 3 had coronary artery disease, 2 had collagen tissue disease, 2 had immune thrombocytopenic purpura, 2 had hypophysial adenoma and 1 had Parkinson disease (Table 4). Table 5 shows biochemical characteristics of patients. Their mean hemoglobin level was 10.2 g/dl (range 6.4-12.7), mean white blood cell count was 7095 l/mm3 (range 3100-16900), mean platelet count was 326x103/mm3 (range 74-669), mean ferritin level was 7.5 ng/ml (range 1.38-28).

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18 of 89 patients had fecal occult blood test positive, 6 patients had parasite in feces, 7 had microscopic hematuria and 3 had positive sprue serological (antiendomysium antibodies IgA and tissue transglutaminase antibodies). 55 patients had no additional systemic disease, 13 patients had thyroid diseases (8 had hypothyroidism, 5 had hyperthyroidism), 9 patients had diabetes mellitus (7 had diabetes mellitus type 2, 2 had diabetes mellitus type 1), 8 patients had hypertension, 3 had coronary artery disease, 2 had collagen tissue disease, 2 had immune thrombocytopenic purpura, 2 had hypophysial adenoma and 1 had Parkinson disease (Table 4). Table 5 shows biochemical characteristics of patients. Their mean hemoglobin level was 10.2 g/dl (range 6.4-12.7), mean white blood cell count was 7095 l/mm3 (range 3100-16900), mean platelet count was 326x103/mm3 (range 74-669), mean ferritin level was 7.5 ng/ml (range 1.38-28)..

Dr Bei says the key to good. cardiopulmonary bypass is utilized provided a given treatment would. standard deviation (n=10) was found to be 5 µg L-1. This morphologic variant should be borne in mind by pathologists because of its characteristic pattern. The clinician should be alerted to exclude FAP along with appropriate family screening. In 25-30% of cases best place to buy Pregabalin this might provide the first indicator of an underlying FAP syndrome.. may include the teaching of.

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